
Project Summary
IMAGEN combines brain imaging, genetics, and psychiatry to increase our understanding of adolescent brain development and behaviour – namely, sensitivity to rewards, impulsivity, and emotional processing. Research teams from London, Nottingham, Dublin, Paris, Berlin, Hamburg, Mannheim and Dresden have been following 2000 young people and their parents from the age of 14, with follow-up assessments at ages 16, 19 and 22.
Data are collected from participants and their parents using the following method:
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Imaging of brain structure refers to the use of advanced technologies to visualize the physical architecture of the brain. These imaging techniques allow for detailed observation of the brain's anatomy, including the shape, size, and integrity of various brain regions.
Structural imaging techniques, such as Magnetic Resonance Imaging (MRI) and Computed Tomography (CT), provide high-resolution images that help in the diagnosis of neurological conditions, assessment of brain injuries, and study of structural changes due to aging or disease. By examining these images, clinicians and researchers can identify abnormalities like tumors, brain lesions, or atrophy, which are crucial for understanding and treating various neurological and psychiatric disorders.
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Cognitive and behavioral assessments are systematic evaluations used to measure an individual’s mental functions and behaviors. These assessments help identify strengths, weaknesses, and patterns in cognitive processes and behavioral responses.
Cognitive assessments focus on evaluating mental abilities such as memory, attention, problem-solving, language skills, and executive functions. Tools like IQ tests, memory tests, and neuropsychological batteries are commonly used. Behavioral assessments, on the other hand, examine how individuals act in various situations, often focusing on patterns that may indicate psychological conditions like anxiety, depression, or ADHD. These assessments involve observations, self-report questionnaires, and structured interviews.
Together, cognitive and behavioral assessments provide a comprehensive picture of an individual's mental health and functioning. They are crucial in diagnosing psychological conditions, guiding treatment plans, and tracking progress over time. These assessments are widely used in clinical settings, educational environments, and research to better understand the interplay between cognition, behavior, and overall mental health.
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Self-report questionnaires are tools that individuals use to assess and reflect on various aspects of their psychological and social well-being. These questionnaires often include a range of psychosocial measures that examine factors such as relationships, emotions, and personality traits.
Self-report questionnaires are widely used in psychological research and clinical practice to gather information directly from individuals about their experiences, thoughts, and feelings. These questionnaires typically include scales or items designed to measure specific psychosocial dimensions, such as the quality of interpersonal relationships, emotional states (like anxiety or depression), and personality characteristics (such as introversion or openness).
The advantage of self-report questionnaires is that they allow individuals to provide insights into their internal experiences, which may not be easily observable. By using validated measures, researchers and clinicians can gain a deeper understanding of how various psychosocial factors interact and contribute to an individual's mental health. These insights are crucial for developing personalized treatment plans, understanding the impact of life events, and studying how different aspects of a person’s psychosocial environment influence their overall well-being.
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Questionnaires related to drug and alcohol use are specialized self-report tools designed to assess an individual's patterns of substance use, including frequency, quantity, and the impact of drug or alcohol consumption on their life.
These questionnaires are essential tools in both clinical and research settings for identifying and understanding substance use behaviors. They typically include questions that explore the extent of drug or alcohol use, the contexts in which substances are consumed, and the consequences of use on physical health, mental well-being, relationships, and daily functioning.
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Blood sampling for genetic and biological analyses involves collecting blood to study the genetic makeup and various biological markers of an individual. These analyses provide insights into an individual’s genetic predispositions and the functioning of different biological systems.
Blood samples are a valuable resource in medical and psychological research, as well as in clinical diagnostics. Genetic analyses from blood samples can reveal information about an individual's DNA, including the presence of genetic mutations, variations, or predispositions to certain diseases. These insights are crucial for understanding inherited conditions, guiding personalized medicine, and identifying potential risks for developing mental health disorders.
In addition to genetic information, blood samples are used to analyze biological markers such as hormone levels, immune function, and metabolic profiles. These biomarkers can indicate the body’s response to stress, the presence of inflammation, or the functioning of the endocrine system. Together, genetic and biological analyses from blood samples provide a comprehensive view of an individual’s health, contributing to more accurate diagnoses, tailored treatments, and deeper insights into the biological underpinnings of various psychological conditions.
Impact for the EU
Mental disorders are a major health problem with a lifetime prevalence of more than 25% (WHO report 2001). According to the WHO, 25% of the general population will have one or more mental disorders during their lifetime: this is a major health problem. In Europe, 34 million people in 2004 had addiction, affective and anxiety disorders which amounted to an annual cost to society of at least 204 billion Euros.
IMAGEN Europe has been widely published in industry journals as well as being referenced in industry and academic reports.
Project Goals
Mental disorders are a major health problem with a lifetime prevalence of more than 25% (WHO report 2001). According to the WHO, 25% of the general population will have one or more mental disorders during their lifetime: this is a major health problem. In Europe, 34 million people in 2004 had addiction, affective, and anxiety disorders, costing society 204 billion Euros. The use of brain imaging methods, such as Magnetic Resonance Imaging (MRI), makes it possible to understand brain mechanisms that underlie personality traits and disorders. Furthermore, we can link them to genetic variation and behavioural changes that are characteristic of disease processes. Recent advances in genomics (the study of genes and their functions) provide new opportunities to identify genes that influence these processes, and to examine their interaction with environmental factors. One of the major challenges addressed in this project is to assemble key biological resources and brain imaging data from human volunteers as well as animal models to understand what underlies individual behavioural differences. The goals of assembling and investigating these materials can be achieved only through a large, inter-disciplinary collaboration that integrates groups specialised in brain imaging, human genetics and behaviour.
Why study adolescents?
75% of mental disorders appear before the age of 25. We know significant brain development takes place during adolescence. Developmental processes during adolescence are crucial for the establishment of behaviours including sensitivity to reward and punishment, impulsivity and emotional responses. These behaviours are important elements in mental disorders. Because this is such an important developmental period, factors including drug-use and stress may result in an increased risk of mental illness. The IMAGEN project aims to understand the consequences of stressors on the brain and behaviour in order to better predict the risk of mental illness and to improve treatment.